Rishi Ramesh Lulla

MD

Providence, RI USA

The Warren Alpert Medical School of Brown University

rishi_lulla.original.jpg

About

Director, Pediatric Hematology/Oncology; Attending Physician, Pediatric Neuro-Oncology; Alan G Hassenfeld Endowed Associate Professor of Pediatrics, The Warren Alpert Medical School of Brown University

Brown University

pediatric brain, central nervous system,  and spinal cord tumors

BrownUniversityMedSchool.jpg

The Warren Alpert Medical School of Brown University

Providence, RI

scientific

Projects

picture for website.png

Data

Completed

Immunotherapeutically-targeting IDO1 in Pediatric High-grade Glioma

Research into adult glioblastoma has revealed a relationship between heightened levels of enzymes that suppress the immune system and a lowered survival rate. Researchers are using the Pediatric Brain Tumor Atlas to explore this relationship in pediatric high-grade pediatric brain cancer.

HGG

Derek_Wainwright.jpg

Derek Wainwright

Northwestern University
Chicago, IL 60611, USA
Asset 20.png

Specimen

Completed

Whole Genome Sequencing and RNA Sequencing of the CBTN Bank for the Pediatric Brain Tumor Atlas

Research into adult cancer has benefited greatly from large scale genomic research. Until now due to the limited resources and availability pediatric brain tumors have not been part of large-scale genomic generation efforts. The CBTN aims to create a comprehensive genomic atlas for use by researchers worldwide to unlock how brain tumors develop, grow, survive, and how they can be treated and cured.

Craniopharyngioma, Medulloblastoma, HGG, (AT/RT), LGG, Ependymoma, Ganglioglioma, DNET, Choroid plexus tumors, Meningioma, DIPG, Oligodendroglioma, Schwannoma, Germinoma, Choroid Plexus Tumors, Subependymal Giant cell Astrocytoma, NGGCTs

ewc_CHOPFoundation(1)01201604184.jpg

Adam Resnick

Children’s Hospital of Philadelphia
Philadelphia, PA, USA
Asset 24.png

Data

Ongoing

Identify Novel Therapeutic Targets and Biomarkers in Non-coding Genome of Pediatric Cancers

Transcription factors are proteins that control the rate of transcription, the process by which information from DNA is copied into a new molecule of RNA. Transcription factor FoxM1 has been found to play a role in the growth of glioblastoma and researchers seek to better understand this connection in the pursuit of targeted therapies.

All Brain Tumor Types, (AT/RT)

zou_lihua.jpg

Lihua Zou

Northwestern University
Chicago, IL 60611, USA
Asset 18.png

Specimen

Completed

Exploration of IDO1 as a Therapeutic Target in Pediatric Central Nervous System Tumors

Recent work points to the enzyme IDO1 as a high value target for the treatment of adult glioma. Researchers will analyze samples provided by the Children’s Brain Tumor Network to determine whether IDO1 could serve as a therapeutic target for pediatric brain tumors as well.

Medulloblastoma, HGG, LGG, Ependymoma, DIPG

rishi_lulla.original.jpg

Rishi Ramesh Lulla

The Warren Alpert Medical School of Brown University
Providence, RI

research

Interests

Medulloblastoma.png

Medulloblastoma

Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature

443
Participants
35
Projects Supported
High-grade glioma_astrocytoma (WHO grade III_IV).png

High-Grade Glioma

High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test

348
Participants
61
Projects Supported
Low-grade astrocymas.png

Low-Grade Glioma

Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su

1003
Participants
23
Projects Supported
Ependymoma.png

Ependymoma

Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors

319
Participants
22
Projects Supported
Brainstem Glioma.png

Diffuse Intrinsic Pontine Glioma

A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[5] New approaches with

136
Participants
30
Projects Supported