Heath Disparities of Pediatric Brain Tumors
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About this
Project
Brain tumors are the leading cause of cancer related death in children. While significant advances have been made in molecularly subgrouping tumors of same pathological diagnosis, little is known about the differences of tumor biology and the clinical outcomes among racial/ethnic populations. By direct implantation of pediatric brain tumor tissues into the matching locations in the brains of SCID mice, we have noticed remarkable differences of tumor take rate between children with different racial/ethnic groups. A recent CDC report also demonstrated an elevated rate of cancer diagnoses in while (184.4/million) when compared with black (133.3/million), American indian/Alasks native (146.7/million) and Asian/pacific islander (144.6/million). All these combined led us to hypothesis that that the overall responses to treatment may also be affected by the racial/ethnic differences in children with brain tumor.
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Scientists
What are the goals of this project?
We aim to look at survival disparity in pediatric brain tumors among children of different racial/ethnic groups.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Explore the data in these informatics portals
related
Histologies
HGG
High-Grade Glioma
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Ependymoma
Ependymoma
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors