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The objective of this project is to investigate whether aberrant splicing candidates resulting from transcriptome-wide dysregulation of alternative splicing in high grade gliomas (HGGs) could be a source for novel neoantigen expression in tumors, that are distinct from missense mutations.
HGG
Patrick Pirrotte
research
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
