Collaborative Center for Translational Mass Spectrometry, The Translational Genomics Research Institute
Aberrant splicing candidates as potential neoantigen expression in HGG
The objective of this project is to investigate whether aberrant splicing candidates resulting from transcriptome-wide dysregulation of alternative splicing in high grade gliomas (HGGs) could be a source for novel neoantigen expression in tumors, that are distinct from missense mutations.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test