- Molecular pathogenesis and therapeutics for paediatric astrocytomas, in particular diffuse intrinsic pontine glioma (DIPG)
- Identification and clinical implementation of novel prognostic and therapeutic markers for paediatric brain tumours
The landscape of pediatric RTK-driven gliomas
Oncogenic fusions involving receptor tyrosine kinases (RTK) provide an excellent opportunity for therapeutic targeting but the clinical and molecular landscape of pediatric RTK-driven gliomas remains largely uncharted. To define clinically-relevant tumor subgroups and assess their prognostic significance, we will evaluate the correlation between molecular and clinical characteristics. This project will provide mechanistic insights into RTK-fused gliomas and enable precision medicine approaches to treat these tumors.
Ana Guerreiro Stücklin
Defining the Role of the Histone 3 (H3.3G34R) Mutation in the Pathogenesis of Pediatric High Astrocytoma
Pediatric high grade astrocytomas are very difficult to treat and decades of clinical trials on adult tumors has failed to improve outcomes. Researchers will utilize cell lines provided by the Children’s Brain Tumor Network to explore newly discovered mutational drivers of this tumor type in an effort to develop pediatric centric therapies.
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with
Splicing is an alternate oncogenic pathway activation mechanism in glioma
Researchers investigate alternative splicing in high grade diffuse glioma in an effort to identify drivers of the tumor's growth.
Robert Siddaway, Scott Milos, Arun Kumaran Anguraj Vadivel, Tara H. W. Dobson, Jyothishmathi Swaminathan, Scott Ryall, Sanja Pajovic, Palak G. Patel, Javad Nazarian, Oren Becher, Michael Brudno, Arun Ramani, Vidya Gopalakrishnan & Cynthia Hawkins