Professor of Pediatrics and Neuroscience
St. Louis Children's Hospital
Dr. Joshua Rubin is a Pediatric Hematologist/Oncologist with nearly 20 years of clinical and lab-based experience focused on pediatric brain tumors. He is co-founder and co-Director of the Pediatric Neuro-Oncology Program at SLCH, Co-Leader of the Neuro-Oncology Focus Group at The Siteman Cancer Center and Chair of the Scientific Advisory Board for the Children’s Brain Tumor Foundation. His lab-based research interests are focused on the molecular basis for sex differences in pediatric brain tumors and novel approaches to compound library screens for preclinical drug development. His clinical research interests are in targeting the cAMP pathway for brain tumor treatment and the development of interventions for cognitive deficits in survivors of pediatric brain tumors.
Sex-specific Gene Expression Signatures in Pediatric Brain Tumors
Human development, disease risk, and response to treatments are often different in males and females. Researchers will interrogate data available through the Pediatric Brain Tumor Atlas to determine whether cancer treatments could be optimized based on such differences.
All Brain Tumor Types
Joshua B. Rubin
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature