Normal human development, disease risk, and response to treatments are often different in males and females. Cancer is no exception, and we are working to determine whether cancer treatments should be optimized independently for males and females. The analysis of the CBTN's Pediatric Brain Tumor Atlas data will be a critical component of moving this important line of investigation forward.
What are the goals of this project?
The goals of this project are to study the different mechanisms involved in male and female in pediatric neuroblastoma development and further our knowledge of the genetic components involved in the development of cancers in both children and adults.
What is the impact of this project?
Expanding this analysis to pediatrics data is needed not only to validate the previous findings, but also to better understanding the difference between children and adults.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas
Joshua B. Rubin, MD, PhD
Dr. Joshua Rubin is a Pediatric Hematologist/Oncologist with nearly 20 years of clinical and lab-based experience focused on pediatric brain tumors. He is co-founder and co-Director of the Pediatric Neuro-Oncology Program at SLCH, Co-Leader of the Neuro-Oncology Focus Group at The Siteman Cancer
St. Louis Children's Hospital
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He i
Children’s Hospital of Philadelphia