Children’s Hospital of Philadelphia
Lea F. Surrey, MD, is a pathologist in the Department of Pathology and Laboratory Medicine at Children's Hospital of Philadelphia.
Data Science, Pathology
Genomic Landscape of Mixed Glial Neuronal Tumors
Mixed Neuronal-Glial Tumors (MNGT) are a benign category of tumor associated with seizures. Using the Pediatric Brain Tumor Atlas, researchers will analyze MNGT in hopes of guiding the development of treatments and predictive assessments.
Lea F. Surrey
Dysembryoplastic Neuroepithelial Tumor
Septal DNET generally presents with symptoms related to obstructive hydrocephalus.[69,70] Septal DNET has an indolent clinical behavior, with most tumors not requiring treatment other than surgery. In a single-institution series that incorporated other literature-reported cases, the median age at pr
Pediatric Blood & Cancer
BRAF Fusions in Pediatric Histiocytic Neoplasms Define Distinct Therapeutic Responsiveness to RAF Paradox Breakers
Pediatric histiocytic neoplasms are hematopoietic disorders frequently driven by the BRAF‐V600E mutation. Here, we identified two BRAF gene fusions (novel MTAP‐BRAF and MS4A6A‐BRAF) in two aggressive histiocytic neoplasms. In contrast to previously described BRAF fusions, MTAP‐BRAF and MS4A6A‐BRAF d
Payal Jain Lea F. Surrey Joshua Straka Pierre Russo Richard Womer Marilyn M. Li Phillip B. Storm Angela J. Waanders Michael D. Hogarty Adam C. Resnick Jennifer Picarsic
American Society of Clinical Oncology
NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome
Neurotrophic tyrosine receptor kinase (NTRK) fusions have been described as oncogenic drivers in a variety of tumors. However, little is known about the overall frequency of NTRK fusion in unselected pediatric tumors. Here, we assessed the frequency, fusion partners, and clinical course in pediatric
Xiaonan Zhao, PhD; Chelsea Kotch, MD; Elizabeth Fox, MD; Lea F. Surrey, MD; Gerald B. Wertheim, MD, PhD; Zubair W. Baloch, MD, PhD; Fumin Lin, PhD; Vinodh Pillai, MD, PhD; Minjie Luo, PhD; Portia A. Kreiger, MD; Jennifer E. Pogoriler, MD, PhD; Rebecca L. Linn, MD; Pierre A. Russo, MD; Mariarita Santi, MD, PhD; Adam C. Resnick, PhD; Phillip B. Storm, MD, PhD; Stephen P. Hunger, MD; Andrew J. Bauer, MD; and Marilyn M. Li, MD