Assistant Professor, Biochemistry and Molecular Genetics
My research goal is to utilize orthogonal genomic data to discover novel cancer drivers and understand their function and underlying mechanism. His group is interested in combining computation and experimental approaches (especially high-throughput sequencing) to understand the regulation and functional consequence of somatic mutations in cancer.
Identify Novel Therapeutic Targets and Biomarkers in Non-coding Genome of Pediatric Cancers
Transcription factors are proteins that control the rate of transcription, the process by which information from DNA is copied into a new molecule of RNA. Transcription factor FoxM1 has been found to play a role in the growth of glioblastoma and researchers seek to better understand this connection in the pursuit of targeted therapies.
All Brain Tumor Types, (AT/RT)
Atypical Teratoid/Rhabdoid Tumor
Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum or
Recurrent Structural Variations of lncRNA Gene CCDC26 in diffuse intrinsic pontine glioma
Supported by whole genome sequencing data provided by CBTN, researchers report on recurrent somatic structural variations, specifically a mutation in the gene CCDC26, related to the development of diffuse intrinsic pontine glioma (DIPG).
Lihua Zou, PhD