Director, Neuro Oncology Program
St. Louis Children's Hospital
Dr. Mohamed Shebl Abdelbaki is the Director of the Pediatric Neuro-Oncology Program at St. Louis Children's Hospital (NCH), and an Associate Professor of Pediatrics at Washington University School of Medicine in St. Louis. He is a member of the Central Nervous System (CNS) Committee at the Children’s Oncology Group (COG), where he also serves as a study committee member for the upcoming CNS non-germinomatous germ cell tumor clinical trial (ACNS2021). Like many other Pediatric Neuro-Oncologists at large academic institutions, his responsibilities and interests include patient care, research, and education. As for patient care, he was awarded one of the highly-esteemed accolades at Nationwide Children’s Hospital (NCH) for excellence in patient care in 2016 (Partners in Care, Partners in Hope Family Centered Care Award). As far as education, he did receive the Distinguished Teaching Award from Saint Louis University School of Medicine in 2015. On the research aspect, he currently lead the early phase clinical trials for the Neuro-Oncology Program at SLCH. He is the principal investigator for several clinical trials in a variety of pediatric brain tumors. Two of his clinical trials have been approved by PNOC; the first trial will test the feasibility of administering Natural Killer (NK) cells in patients with recurrent HGGs, while the second trial (PNOC021 )was also approved by Novartis pharmaceuticals and entails testing the combination of Everolimus and Trametinib in children with recurrent low-grade gliomas.
St. Louis Children's Hospital
Multi-institutional analysis of recurrent central nervous system germinomas
Germinomas are a rare pediatric brain cancer with high rates of relapse, the process by which a cancer returns after successful treatment. Researchers across the United states, Australia, and Brazil will be requested to contribute data as researchers aim to curate a database of information related to relapsed central nervous system germinomas. Reports of relapsed germinomas are rare and exist in two main contexts, as part of a large trial or within case reports. There is, to the researchers knowledge, no large, multi-institutional database that focus on relapsed germinomas. Having this specific data including patients from different institutions and who received varying types of treatments available for analysis could provide new insight into the biology of germinomas and new avenues for treatment. Pulling this information together could also help researchers and clinical professionals evaluate patterns in the germinoma patient population such as location, timing, and treatment related to cases of relapse. The CBTN database encompasses germinoma cases from multiple institutions and trials therefore supports the efficiency and impact of this project.
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test