Assistant Professor, Director, Collaborative Center for Translational Mass Spectrometry,
The Translational Genomics Research Institute
Patrick Pirrotte graduated with a Ph.D. in Neurobiology from Louis Pasteur University, Strasbourg, France (now University of Strasbourg) in November 2007. His semi-industrial thesis pioneered the use of high-resolution dynamic Secondary Ion Mass Spectrometry in Life Sciences. Since late 2013, Patrick is the Technical Director of TGen’s Collaborative Center for Translational Mass Spectrometry. The Collaborative Center for Translational Mass Spectrometry has been conceived from ground up as a high-end clinical proteomics platform that can accommodate large volumes of patient samples.
Aberrant splicing candidates as potential neoantigen expression in HGG
The objective of this project is to investigate whether aberrant splicing candidates resulting from transcriptome-wide dysregulation of alternative splicing in high grade gliomas (HGGs) could be a source for novel neoantigen expression in tumors, that are distinct from missense mutations.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test