Professor of Biomedical Informatics
Harvard Medical School
Peter Kharchenko received a PhD in biophysics at Harvard University, studying gene regulation and metabolic networks under the advisement of George Church. He then completed a four-year postdoctoral fellowship in computational biology and genomics in the laboratory of Peter Park. He is currently studying the epigenetic mechanisms that regulate the growth and maintenance of normal tissues as well as the disruptions of the epigenetic state that contribute to a variety of disorders.
Identifying tumor cell vulnerabilities in recurrent/progressive human medulloblastomas by single-cell RNA-seq
The knowledge of the pathways and target genes that can drive tumors into less recurrent/progressive and rather sensitive to treatment can be a key for cancer treatment. To achieve this, we need to understand heterogeneity within the cancer cells and the cell clones that survive treatment and/or
Medulloblastomas comprise the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinica