Professor of Biomedical Informatics
Harvard Medical School
Peter Kharchenko received a PhD in biophysics at Harvard University, studying gene regulation and metabolic networks under the advisement of George Church. He then completed a four-year postdoctoral fellowship in computational biology and genomics in the laboratory of Peter Park. He is currently studying the epigenetic mechanisms that regulate the growth and maintenance of normal tissues as well as the disruptions of the epigenetic state that contribute to a variety of disorders.
Identifying Tumor Cell Vulnerabilities in Recurrent/Progressive Human Medulloblastomas by Single-cell RNA-seq
Medulloblastoma is the most common form of brain cancer, and many patients experience tumor progression/recurrence despite treatment. Using flash frozen samples provided by the Children’s Brain Tumor Network, researchers will try to better understand medulloblastoma recurrence.
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature