Children's Hospital of Philadelphia
Children’s Hospital of Philadelphia
In Silico Neo-antigen Detection in High-grade Pediatric Brain Tumors Utilizing RNA-seq and WGS
Immunotherapy is a promising form of therapy for high grade tumors, but more comprehensive research is needed. Through accessing the Pediatric Brain Tumor Atlas, researchers will produce data that could lead to the development of patient-specific treatments.
Medulloblastoma, HGG, (AT/RT), DIPG
Development of CAR-T Cell Therapy for Atypical Teratoid/Rhabdoid Tumors
Atypical teratoid rhabdoid tumors (ATRT) are an aggressive pediatric brain tumor and expanded treatment options are necessary to enhance survival outcomes for patients. Using samples provided by CBTN, researchers will be exploring CAR-T therapy as a new option for ATRT patients.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Atypical Teratoid/Rhabdoid Tumor
Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum or