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Philadelphia, PA, USA
Neurosurgery
scientific
Data
Ongoing
Immunotherapy holds great promise in the treatment of pediatric central nervous system tumors. This is especially true in high grade tumor pathologies (high grade glioma, DIPG, ATRT, medulloblastoma, etc.) where the underlying biology does not seem to involve targetable driver mutations, but rath
Medulloblastoma, HGG, Atypical teratoid/rhabdoid tumor (AT/RT), DIPG…
Peter Madsen
research
HGG
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective
Atypical teratoid/rhabdoid tumor (AT/RT)
Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum
