Director, Center for RNA Biology, and Associate Professor, Department of Oncology, Johns Hopkins University School of Medicine
The Johns Hopkins University and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Dr. Perera is director of the Center for RNA Biology at Johns Hopkins All Children's Hospital, a senior scientist in the Cancer & Blood Disorders Institute and an associate professor of oncology in the Johns Hopkins University School of Medicine. He also has a secondary affiliation with the Johns Hopkins All Children’s Institute for Fundamental Biomedical Research. He uses biology, analytic genomics and bioinformatics to seek patterns that can lead to treatments for aggressive cancers. Dr. Perera’s research focuses on genes and identifying those susceptible to changes that lead to disease. He seeks to identify these changes early in life, which would allow early intervention through surgery or therapies that could prevent or alter the course of the disease.
Johns Hopkins Medicine
Identification of Circulating Noncoding RNAs and Metabolites in Cerebrospinal Fluid(CSF) in Medulloblastoma Patients
Medulloblastoma is the most common pediatric brain tumor, and yet there is still much to be learned in order to effectively treat this disease. Researchers will utilize cerebrospinal fluid samples provided by the Children’s Brain Tumor Network in an effort to identify molecular markers that could lead to improved diagnostics, therapies and outcomes.
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
Researchers identify cerebrospinal fluid signatures that can be used to sensitively detect medulloblastoma.
Bongyong Lee, Iqbal Mahmud, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett & Ranjan J. Perera