Research Assistant Professor
Quantitative Medicine & Systems Biology Divison, The Translational Genomics Research Institute
Dr. Halperin is broadly interested in developing and applying methods to gain insight from cancer genomic data that can improve our understanding or tumor biology and inform clinical decision-making. Her current research focuses on the following areas 1) improving calling of variants in difficult samples such as tumor samples lacking matched germline samples, 2) integration of variant calls across tumor samples and data types for improved understanding of tumor heterogeneity and functional implications of alterations, 3) application of immunoinformatics methods to help elucidate how the somatic alterations may allow the patient’s immune system to recognize the tumor.
Aberrant splicing candidates as potential neoantigen expression in HGG
The objective of this project is to investigate whether aberrant splicing candidates resulting from transcriptome-wide dysregulation of alternative splicing in high grade gliomas (HGGs) could be a source for novel neoantigen expression in tumors, that are distinct from missense mutations.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test