Research Fellow in Biomedical Informatics
Harvard Medical School
Shenglin Mei received his PhD in Bioinformatics from Tongji University under the supervision of Professor Xiaole Shirley Liu. Mei's research was focused on gene transcriptional and epigenetic regulation in cancer through multiple genomic data integration. He is currently working on intratumoral heterogeneity and microenvironment in metastatic and primary human tumors based on single-cell sequencing data.
Identifying Tumor Cell Vulnerabilities in Recurrent/Progressive Human Medulloblastomas by Single-cell RNA-seq
Medulloblastoma is the most common form of brain cancer, and many patients experience tumor progression/recurrence despite treatment. Using flash frozen samples provided by the Children’s Brain Tumor Network, researchers will try to better understand medulloblastoma recurrence.
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature