Sriram Venneti

Scientific Committee

Ann Arbor, MI 48109

Michigan Medicine C.S. Mott Children’s Hospital



Associate Professor


Dr. Venneti’s lab studies the biology of pediatric and adult brain tumors (such as gliomas thought to be of glial origin) with a specific focus on understanding the regulation of cancer metabolism and epigenetics as drivers of pathology. Cancer cells including brain tumor cells reprogram their metabolism by altering nutrient uptake and metabolism to support their aberrant proliferation and survival. The two principle nutrients that cancer cells use are the sugar glucose and the amino acid glutamine. These two nutrients are central to many anabolic processes including the biosynthesis of ATP, nucleotides, proteins and lipids. Recent years have seen the emergence of the concept that metabolic reprogramming in cancer cells is not a passive process. Rather, oncogenes and inactivated tumor suppressors in cancer cells directly reprogram the metabolism of cancer cells. These metabolic pathways can directly rewire the epigenome and provide novel avenues to develop newer diagnostic and therapeutic targets.

Michigan Medicine C.S. Mott Children’s Hospital

Michigan Medicine C.S. Mott Children’s Hospital

Ann Arbor, Michigan, USA