Professor of Neurosurgery and Pediatrics
Children's Hospital of Colorado
My research interests focus in 3 areas:
1. Pediatric Brain Tumors - I assembled and lead the only multi center consortium in North America that focuses on the improvement of therapies for pediatric craniopharyngioma: Advancing Treatment for Pediatric Craniopharyngioma. We use tissue and clinical data to study gene expression and correlate this with potential available medical therapies. Further information regarding our consortium can be found at: https://www.childrenscolorado.org/pediatric-innovation/research/neuroscience/atpc-consortium/
2. Hydrocephalus - I am the Children's Hospital Colorado site principal investigator for the Hydrocephalus Clinical Research Network. This is a multicenter consortium that completes clinical outcomes research aimed at improving treatment for children with hydrocephalus: http://www.hcrn.org
3. Pediatric cervical spine disease. I am a member of the Pediatric Craniocervical Society, which is a small group of pediatric neurosurgeon who conduct research aimed at improving therapies for children with diseased of the cervical spine and occipitocervical region.
Children’s Hospital of Philadelphia
Investigating Disease Mechanism In Adamantinomatous Craniopharyngioma Using New Cell Line Models
Adamantiomatious craniopharyngioma (ACP) is an intracranial tumor with no currently available targeted drug therapeutics. Using cell lines provided by the Children’s Brain Tumor Network, researchers will develop new models for use in identifying therapeutic opportunities for this disease.
Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).Craniopharyngiomas are usually part solid mass and