Comprehensive Genomic and Immune Signature Profiling of Ependymoma and Diffuse Intrinsic Pontine Glioma

Email Principal Investigator
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Kathleen M. Schieffer

Nationwide Children's Hospital
700 Children's Drive Columbus, OH 43205



Internal funding

About this


Brain tumors are the most common form of pediatric tumor, and while advancements have been made in treating a variety of tumor types, the need for comprehensive research into all pediatric brain tumors is great. Certain subtypes of ependymoma are associated with poor outcomes for patients as well as with diffuse intrinsic pontine glioma (DIPG) brain tumor patients. Both would benefit greatly from an expansion of comprehensive study of their genome. This study aims to do just that by taking an approach that combines genetic and epigenetic (non-gene) influences with data on immune response. The Pediatric Brain Tumor Atlas will give researchers access to a unique set of data necessary to carry out this research.

Ask The


Ask the scientists

What are the goals of this project?

Researchers will perform comprehensive analysis on ependymoma and DIPG, including a comparison and contrast of their genetic underpinnings.

What is the impact of this project?

Ependymoma and DIPG are associated with poor outcomes for patients. Comprehensive understanding of the genetic, epigenetic, and immune response of these tumors will pave the way for the development of more effective treatments.

Why is the CBTN request important to this project?

The broad data available through the Pediatric Brain including rare specimens of ependymoma and DIPG is necessary to complete this comprehensive analysis.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals