Discover New Therapeutics for DIPG using a Systems-Based Approach

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National Institute of Health

About this


Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of brainstem cancer that targets young children. Complete surgical removal is not possible, and chemotherapy and radiotherapy are currently only effective in controlling pain and discomfort. New therapies are greatly needed to combat the poor prognosis of this cancer but they can not be developed without further research. While sequencing DNA gives a genetic profile of a tumor, sequencing RNA reflects only the sequences that are actively expressed in the cells leading researchers to new possible therapeutic targets. Therefore, researchers on this project will be analyzing the RNA sequencing data from pediatric brain cancer patients. Researchers will expand their current sample size with access to RNA sequencing data from the Pediatric Brain Tumor Atlas.

Ask The


Ask the scientists

What are the goals of this project?

Researchers will analyze RNA sequencing data in an effort to identify new targets for therapy for patients with DIPG.

What is the impact of this project?

Researchers in this project seek to identify new therapeutic targets that will propel the development of new targeted therapies for patients with DIPG.

Why is the CBTN request important to this project?

Researchers need comprehensive data on rare pediatric brain cancers to complete this work, and the Pediatric Brain Tumor Atlas provides them with enough to considerably expand their dataset.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals