Director, Pediatric Neuro-Oncology
Hassenfeld Children's Hospital at NYU Langone
Theodore Nicolaides is an investigator at Hassenfeld Children's Hospital at NYU Langone in New York, New York.
Discover New Therapeutics for DIPG using a Systems-Based Approach
Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of pediatric brain cancer associated with poor outcomes. Researchers will use data from the Pediatric Brain Tumor Atlas in the pursuit of new therapies for patients with DIPG.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
A Cavernoma is a cluster of abnormal blood vessels, usually found in the brain and spinal cord. They're sometimes known as cavernous angiomas, cavernous hemangiomas, or cerebral cavernous malformation (CCM).(Source: NCI)
Reversal of Cancer Gene Expression Identifies Repurposed Drugs for Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is an aggressive tumor that requires new treatment approaches. Utilizing cell lines provided by CBTN, researchers have identified clinically available drugs for DIPG treatment.
Guisheng Zhao, Patrick Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin S. Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri, Javad Nazarian, Michael E. Pacold, Daniel J. Brat, Theodore Nicolaides, Bin Chen, Rintaro Hashizume