Director, Pediatric Neuro-Oncology
Hassenfeld Children's Hospital at NYU Langone
Theodore Nicolaides is an investigator at Hassenfeld Children's Hospital at NYU Langone in New York, New York.
Discover new therapeutics for DIPG using a systems-based approach
Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of brainstem cancer that targets young children. Complete resection is not possible, and chemotherapy and radiotherapy are currently only palliative. Prognosis is dismal. Novel approaches are urgently needed to treat this disease.
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective
Low-Grade astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still suffer from the eff