Treehouse Childhood Cancer Initiative: Identification of Therapeutic Leads for Individual Pediatric Cancer Patients via Can-Cancer Analysis
Email Principal Investigator
David Haussler
CBTN Data
CBTN Participants
Backer
St. Baldrick's Foundation
California Initiative to Advance Precision Medicine
Unravel Pediatric Cancer
Team G Pediatric Cancer Foundation
Live For Others Foundation
Alex's Lemonade Stand Foundation for Childhood Cancer Research
American Association for Cancer Research
About this
Project
The information stored in DNA dictates how cells make proteins and other molecules. Cancer alters this gene expression, resulting in tumors. Oncogenes, genes with the potential to cause cancer, can be utilized in the treatment of cancer itself but they must first be identified. Using the Pediatric Brain Tumor Atlas, researchers are comparing data across many forms of pediatric brain cancers. Through the comparison of gene expression across tumor types and individual patients using RNA sequencing, researchers are building an open-access resource for others to guide therapeutic decisions. For more information visit the Treehouse Project.
Ask The
Scientists
What are the goals of this project?
Data from as many pediatric and rare adult cancers will be used to create a resource to guide therapeutic decision making.
What is the impact of this project?
Using the resource created by this project, researchers will explore the utility of comparing individual patient data to data of individual cancer types further guiding the decisions of medical professionals.
Why is the CBTN request important to this project?
Access to comprehensive data about pediatric brain cancer is rare, making access to the Pediatric Brain Tumor Atlas invaluable in supporting the broad reach of this project.
Project
Results
So far the compendia contain gene expression data for nearly 13,000 tumors in total, over 3,000 of which are from pediatric or young adult patients. We have demonstrated the feasibility of our comparative RNA-seq analysis in a clinical setting, and showed that potentially actionable findings in pediatric cancer cases increase when RNA-seq data is considered.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.
Explore the data in these informatics portals
Meet The
Team
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Santa Cruz, CA, USA
600 1st Avenue, 1st Floor, Seattle, Washington 98104
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Santa Cruz, CA, USA
Institutions
Satellite
UC Santa Cruz Treehouse Childhood Cancer Initiative
Joined onThe Treehouse Childhood Cancer Initiative was established to analyze genomic data of children with cancer in the context of large data sets of both pediatric and adult cancers. This allows researchers to identify situations where an available drug is predicted to work for a given patient’s tumor. Tr
Blue Marble Space Institute of Science, NASA GeneLab
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