Treehouse Childhood Cancer Initiative: Identification of Therapeutic Leads for Individual Pediatric Cancer Patients via Can-Cancer Analysis

Email Principal Investigator
Ongoing
Data
All Brain Tumor Types
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David Haussler

UC Santa Cruz Treehouse Childhood Cancer Initiative
Santa Cruz, CA, USA

CBTN Data

966

CBTN Participants

Backer

St. Baldrick's Foundation

California Initiative to Advance Precision Medicine

Unravel Pediatric Cancer

Team G Pediatric Cancer Foundation

Live For Others Foundation

Alex's Lemonade Stand Foundation for Childhood Cancer Research

American Association for Cancer Research

About this

Project

The information stored in DNA dictates how cells make proteins and other molecules. Cancer alters this gene expression, resulting in tumors. Oncogenes, genes with the potential to cause cancer, can be utilized in the treatment of cancer itself but they must first be identified. Using the Pediatric Brain Tumor Atlas, researchers are comparing data across many forms of pediatric brain cancers. Through the comparison of gene expression across tumor types and individual patients using RNA sequencing, researchers are building an open-access resource for others to guide therapeutic decisions. For more information visit the Treehouse Project.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Data from as many pediatric and rare adult cancers will be used to create a resource to guide therapeutic decision making.

What is the impact of this project?

Using the resource created by this project, researchers will explore the utility of comparing individual patient data to data of individual cancer types further guiding the decisions of medical professionals.

Why is the CBTN request important to this project?

Access to comprehensive data about pediatric brain cancer is rare, making access to the Pediatric Brain Tumor Atlas invaluable in supporting the broad reach of this project.

Project

Results

So far the compendia contain gene expression data for nearly 13,000 tumors in total, over 3,000 of which are from pediatric or young adult patients. We have demonstrated the feasibility of our comparative RNA-seq analysis in a clinical setting, and showed that potentially actionable findings in pediatric cancer cases increase when RNA-seq data is considered.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals

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Meet The

Team

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Scientific Committee

Principal Investigator

David Haussler, PhD

David Haussler develops new statistical and algorithmic methods to explore the molecular function, evolution, and disease process in the human genome, integrating comparative and high-throughput genomics data to study gene structure, function, and regulation (CV,  publications). As a collaborator on

UCSC TreeHouse Childhood Cancer Initiative.jpg

UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Scientific Committee

Holly Beale, PhD

Holly is an investigator at UC Santa Cruz Treehouse Childhood Cancer Initiative in Santa Cruz, California.

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UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Scientific Committee

Sofie Salama, PhD, BS

Sofie Salama’s work involves using pluripotent stem cells from a variety of primate species and high throughput sequencing methods to study how genome evolution affects human development and disease. Since 2004, she has collaborated closely with Professor David Haussler, Scientific Director of the U

UCSC TreeHouse Childhood Cancer Initiative.jpg

UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Scientific Committee

Principal Investigator

Olena Morozova Vaske, PhD

Dr. Vaske is the Co-Founder of the Treehouse Childhood Cancer Initiative at the University of California Santa Cruz Genomics Institute where she is an Assistant Professor of Molecular, Cell and Developmental Biology. She is a Fellow of the Canadian College of Medical Geneticists and holds the Univer

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UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Isabel Bjork

Isabel Bjork joined the University of California, Santa Cruz to contribute strategic and operational expertise to bring essential testing capacity to Santa Cruz. She has a background in international legal reform in developing countries, conflict management, and organizational change. Isabel is a li

UCSC TreeHouse Childhood Cancer Initiative.jpg

UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Alfred Geoffrey Lyle, MS

UCSC TreeHouse Childhood Cancer Initiative.jpg

UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Ellen Kephart

Our research at Treehouse could potentially change the face of childhood cancer treatment. My personal goal is to create software infrastructure that automates our protocols and enables our scientists to easily experiment with different data analysis techniques.

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UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Lauren Sanders, PhD

Data processing and analysis of space-related omics data at NASA GeneLab

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Anouk van den Bout

UCSC TreeHouse Childhood Cancer Initiative.jpg

UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Katrina Learned

I am working at Treehouse because I am passionate about finding better treatments and cures for children with cancer, and because I have the utmost confidence in the abilities and methods of the Treehouse team

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UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA
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Allison Cheney

UCSC TreeHouse Childhood Cancer Initiative.jpg

UC Santa Cruz Treehouse Childhood Cancer Initiative

Santa Cruz, CA, USA

related

Histologies