Treehouse Childhood Cancer Initiative: Identification of Therapeutic Leads for Individual Pediatric Cancer Patients via Can-Cancer Analysis

Email Principal Investigator
All Brain Tumor Types
Asset 8.png

David Haussler

UC Santa Cruz Treehouse Childhood Cancer Initiative
Santa Cruz, CA, USA



CBTN Participants


St. Baldrick's Foundation

California Initiative to Advance Precision Medicine

Unravel Pediatric Cancer

Team G Pediatric Cancer Foundation

Live For Others Foundation

Alex's Lemonade Stand Foundation for Childhood Cancer Research

American Association for Cancer Research

About this


The information stored in DNA dictates how cells make proteins and other molecules. Cancer alters this gene expression, resulting in tumors. Oncogenes, genes with the potential to cause cancer, can be utilized in the treatment of cancer itself but they must first be identified. Using the Pediatric Brain Tumor Atlas, researchers are comparing data across many forms of pediatric brain cancers. Through the comparison of gene expression across tumor types and individual patients using RNA sequencing, researchers are building an open-access resource for others to guide therapeutic decisions. For more information visit the Treehouse Project.

Ask The


Ask the scientists

What are the goals of this project?

Data from as many pediatric and rare adult cancers will be used to create a resource to guide therapeutic decision making.

What is the impact of this project?

Using the resource created by this project, researchers will explore the utility of comparing individual patient data to data of individual cancer types further guiding the decisions of medical professionals.

Why is the CBTN request important to this project?

Access to comprehensive data about pediatric brain cancer is rare, making access to the Pediatric Brain Tumor Atlas invaluable in supporting the broad reach of this project.



So far the compendia contain gene expression data for nearly 13,000 tumors in total, over 3,000 of which are from pediatric or young adult patients. We have demonstrated the feasibility of our comparative RNA-seq analysis in a clinical setting, and showed that potentially actionable findings in pediatric cancer cases increase when RNA-seq data is considered.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals