Co-Founder Treehouse Initiative; Distinguished Professor, Biomolecular Engineering, UC Santa Cruz
University of California, Santa Cruz
David Haussler develops new statistical and algorithmic methods to explore the molecular function, evolution, and disease process in the human genome, integrating comparative and high-throughput genomics data to study gene structure, function, and regulation (CV, publications). As a collaborator on the international Human Genome Project, his team posted the first publicly available computational assembly of the human genome sequence. His team subsequently developed the UCSC Genome Browser, a web-based tool that is used extensively in biomedical research. He is Santa Cruz Campus co-director of QB3, an HHMIInvestigator, and on scientific advisory boards of the Broad Institute, NYGC and CZI. He also co-founded the Genome 10K Project, co-founded the Treehouse Childhood Cancer Project, and is a co-founder of the Global Alliance for Genomics and Health (GA4GH), a coalition of the top research, health care, and disease advocacy organizations. He is a member of the National Academy of Sciences and the American Academy of Arts & Science.
Please visit the Haussler-Salama Lab website for more information.
Treehouse Childhood Cancer Initiative: Identification of Therapeutic Leads for Individual Pediatric Cancer Patients via Can-Cancer Analysis
The Treehouse Childhood Cancer Initiative research focuses on the value of tumor gene expression analysis using RNA sequencing for detecting aberrations in the genome and epigenome. The main objective of this project is to identify therapeutically actionable oncogenes with outlier expression in a
Medulloblastomas comprise the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinica
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective
Low-Grade astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still suffer from the eff
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumo
Cold Spring Harbor Molecular Case Studies
Data Sharing for Clinical Utility
Genomic data offer valuable insights that can be used to help find treatments and cures for disease. Precision medicine, defined by the NIH as “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each pe
Isabel Bjork, Jennifer Peralez, David Haussler, Sheri L. Spunt, and Olena Morozova Vaske