Broad Institute to MIT and Harvard
Broad Institute of MIT and Harvard
Analysis of Chromatin Pathways as Regulators of High Grade Glioma Gene Expression Patterns
Comprehensive research into high grade gliomas is necessary to find new effective therapies. Using the Pediatric Brain Tumor Atlas, researchers will identify patterns in gene expression that could pave the way for the development of new therapeutics.
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with