Analysis of Chromatin Pathways as Regulators of High Grade Glioma Gene Expression Patterns

Email Principal Investigator
Epigenetic Dysregulation
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Jamie Anastas

Boston Children's Hospital
Boston, MA USA


About this


Patients with high grade gliomas (HGG) face considerable treatment challenges and comprehensive research is needed to find new therapeutic options. Using the Pediatric Brain Tumor Atlas, researchers will identify genes that are expressed differently in patient-derived tumor samples compared to normal tissue samples. Gene expression, the process by which the genetic information is used to direct production of proteins in the body, is crucial in understanding the similarities and differences across tumor types. Additionally, these genetic signatures will be used in comparison to lab-grown tumor cell lines that have been genetically manipulated or treated with various drugs. Researchers hope to analyze these comparisons and identify patterns in gene expression that could pave the way for the development of new therapies.

Ask The


Ask the scientists

What are the goals of this project?

Researchers will identify and compare tumor samples, normal tissue samples, and lab grown tumor samples in an effort to identify patterns in gene expression.

What is the impact of this project?

The identification of patterns in gene expression across tumor types could lead to the development of new targeted therapies.

Why is the CBTN request important to this project?

The breadth and depth of data available through the Pediatric Brain Tumor Atlas will be pivotal in supporting this project.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas.

Explore the data in these informatics portals