Research Group Head, Developmental and Cancer Biology
Hudson Institute of Medical Research
Dr. Jason Cain is Head of the Developmental and Cancer Biology research group in Hudson Institute’s Centre for Cancer Research and a Chief Investigator for the Hudson Monash Paediatric Precision Medicine Program. A developmental and cancer biologist, Dr. Cain is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease, including paediatric connective tissue (sarcomas), paediatric brain cancers (including atypical teratoid rhabdoid tumours, medulloblastoma and diffuse intrinsic pontine glioma), and lung cancer.
Hudson Monash Paediatric Precision Medicine Program
There is a great need to find new targets for pediatric brain cancer therapeutics, requiring comprehensive analysis of tumor types. Access to the unique dataset available through the Pediatric Brain Tumor Atlas and computational support from CBTN will allow researchers to carry out this research.
All Brain Tumor Types
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature
Atypical Teratoid/Rhabdoid Tumor
Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum or
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor. New approaches with