John Prensner
Ann Arbor, MI USA
Michigan Medicine C.S. Mott Children’s Hospital
About
Assistant Professor
University of Michigan
Dr. Prensner is a physician-scientist and pediatric neuro-oncologist in the Chad Carr Pediatric Brain Tumor Center at the University of Michigan. His clinical work focuses on children with high-risk brain tumors and his research advances novel genomics-based work on the underpinnings of these cancers. Dr. Prensner’s lab emphasizes traditional experimental techniques, innovative -omics technologies, and computational data science to explore noncanonical mechanisms within the genomes of pediatric brain tumors. His work has developed a special emphasis on the dark proteome. He has spearheaded numerous international collaborations to advance his work, many of which involve CBTN- and PNOC-affiliated institutions. He co-chairs the international TransCODE consortium on the non-canonical proteome and is helping to lead work with CBTN and the NCI CPTAC program for pediatric gliomas. He is Co-PI/Co-I on several early-phase studies in pediatric brain tumors.
Expertise
Neuro-oncology
Michigan Medicine C.S. Mott Children’s Hospital
research
Interests
Medulloblastoma
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature
Atypical Teratoid/Rhabdoid Tumor
Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum or
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[5] New approaches with