Nadia Dahmane
About
Assistant Professor of Developmental Biology in Neurological Surgery
Weill Cornell Medicine Pediatric Brain & Spine Center
Dr. Dahmane’s current research focuses a group of proteins called transcription factors that regulate how different genes are expressed during both brain development and brain cancer progression. Her laboratory has identified a critical novel transcription factor protein (called RP58) that is indispensable for brain development; its deletion in a mouse model leads to microcephaly, a birth defect affecting the size of the brain. New work from her group investigates how this protein may also be involved in brain tumor development.
scientific
Projects
Data
Specimen
Molecular Characterization
Blood Brain Barrier
Assay Development
Planning
Characterizing the Blood-Brain-Barrier in Pediatric Brain Tumors
The blood brain barrier is an issue clinicians face when trying to deliver drugs for the treatment of brain cancers. Using rare samples and imaging data provided by the Children’s Brain Tumor Atlas, researchers will investigate new avenues for drug delivery.
HGG, LGG
Mark M. Souweidane
Specimen
Molecular Characterization
Drug/CRISPR Screen
Ongoing
Elucidating Heterogeneity of Resistance Across Molecular Subgroups of Pediatric Ependymomas to Inform Future Therapeutics
Intracranial ependymomas are a common pediatric brain cancer with many subgroups that may respond differently to different therapies. Using cell lines provided by the Children’s Brain Tumor Network, researchers seek to better understand these differences in an effort to advance positive patient outcomes.
Ependymoma
Jeffrey Greenfield
Medulloblastoma, HGG, LGG, Ependymoma, Meningioma, Schwannoma
Nadia Dahmane