Asset 1.png
dahmane-nadia-145x180.original.jpg

Nadia Dahmane

Weill Cornell Medicine
New York, NY, USA

CBTN Data

About this

Project

Meningiomas are the most common tumors occurring in the brain and spine. About 80% of them show benign features responsive to surgery alone. 20%, however, require extensive treatment including repeat surgery, radiation, and/or chemotherapy, and in many cases the tumors still recur. Pediatric meningiomas, however, are extremely rare tumors and are often of the more aggressive form. It is thought that the underlying biology of pediatric meningiomas is different from their adult counterparts, and this study seeks to investigate those differences. Whole Genome Sequencing (WGS), which identifies the base chemicals that make up DNA, will be carried out on specimens from the Pediatric Brain Tumor Atlas. Researchers aim to gain a deeper understanding of pediatric meningiomas that could establish new therapies designed specifically for the pediatric population.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Pediatric meningiomas are not as well understood at adult meningiomas and researchers in this project seek to close that knowledge gap in the pursuit of targeted therapies.

What is the impact of this project?

Through addressing the differences between adult and pediatric meningiomas, researchers are paving the way for the development of new targeted therapies for pediatric populations. The data generated will help characterize this tumor type and be shared with the research community.

Why is the CBTN request important to this project?

Pediatric meningiomas are rare tumors, but the Pediatric Brain Tumor Atlas will give researchers access to the specimens needed to carry out this research.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas

Explore the data in these informatics portals

Cavativa-Logo.png
Kids_First_Graphic_Horizontal_OL_FINAL.DRC-01.png

related

Histologies

Medulloblastoma.png

Medulloblastoma

Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature

443
Participants
35
Projects Supported
High-grade glioma_astrocytoma (WHO grade III_IV).png

High-Grade Glioma

High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test

348
Participants
62
Projects Supported
Low-grade astrocymas.png

Low-Grade Glioma

Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su

1003
Participants
23
Projects Supported
Ependymoma.png

Ependymoma

Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors

319
Participants
22
Projects Supported
Meningioma.png

Meningioma

A meningioma is a primary central nervous system (CNS) tumor. This means it begins in the brain or spinal cord. Overall, meningiomas are the most common type of primary brain tumor.  However, higher grade meningiomas are very rare. 

83
Participants
5
Projects Supported
Schwannoma.png

Schwannoma

Schwannoma is a rare type of tumor that forms in the nervous system. Schwannoma grows from cells called Schwann cells. Schwann cells protect and support the nerve cells of the nervous system. Schwannoma tumors are often benign, which means they are not cancer. But, in rare cases, they can become can

54
Participants
6
Projects Supported