Meningiomas are the most common tumors occurring in the brain and spine. About 80% of them show benign features responsive to surgery alone. 20%, however, require extensive treatment including repeat surgery, radiation, and/or chemotherapy, and in many cases the tumors still recur. Pediatric meningiomas, however, are extremely rare tumors and are often of the more aggressive form. It is thought that the underlying biology of pediatric meningiomas is different from their adult counterparts, and this study seeks to investigate those differences. Whole Genome Sequencing (WGS), which identifies the base chemicals that make up DNA, will be carried out on specimens from the Pediatric Brain Tumor Atlas. Researchers aim to gain a deeper understanding of pediatric meningiomas that could establish new therapies designed specifically for the pediatric population.
What are the goals of this project?
Pediatric meningiomas are not as well understood at adult meningiomas and researchers in this project seek to close that knowledge gap in the pursuit of targeted therapies.
What is the impact of this project?
Through addressing the differences between adult and pediatric meningiomas, researchers are paving the way for the development of new targeted therapies for pediatric populations. The data generated will help characterize this tumor type and be shared with the research community.
Why is the CBTN request important to this project?
Pediatric meningiomas are rare tumors, but the Pediatric Brain Tumor Atlas will give researchers access to the specimens needed to carry out this research.
The Children's Brain Tumor Network contributed to this project by providing access to the Pediatric Brain Tumor Atlas
Nadia Dahmane, PhD
Dr. Dahmane’s current research focuses a group of proteins called transcription factors that regulate how different genes are expressed during both brain development and brain cancer progression. Her laboratory has identified a critical novel transcription factor protein (called RP58) that is indisp
Weill Cornell Medicine
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a
Children’s Hospital of Philadelphia
Bo Zhang, BS
Bo Zhang is a Bioinformatics Engineer responsible for several initiatives, including The Children’s Brain Tumor Tissue Consortium (CBTTC) and Cavatica. His responsibilities include monitoring and assessing data quality, variant prioritization, data modeling, and statistical analysis. He identifies
Children’s Hospital of Philadelphia
Weill Cornell MedicineJoined on
The Weill Cornell Medicine Pediatric Brain and Spine Center, located on the Upper East Side campus of New York-Presbyterian/Weill Cornell Medical Center, is nationally recognized for its leadership in the treatment of disorders of the central nervous system in children, particularly brain and spinal
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
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