Children's Hospital of Philadelphia
Bo Zhang is a Bioinformatics Engineer responsible for several initiatives, including The Children’s Brain Tumor Tissue Consortium (CBTTC) and Cavatica. His responsibilities include monitoring and assessing data quality, variant prioritization, data modeling, and statistical analysis. He identifies, ports/develops, maintains and makes accessible all bioinformatics software on Unix/Linux platforms. He also analyzes user requirements and determines software, hardware and data management needs.
Children’s Hospital of Philadelphia
Deciphering the Molecular Characteristics of Pediatric Meningiomas
Pediatric meningiomas are extremely rare tumors and are often of an aggressive form unresponsive to available treatments. Specimens from the Pediatric Brain Tumor Atlas will allow researchers to study this rare tumor in an effort to develop targeted therapies.
Medulloblastoma, HGG, LGG, Ependymoma, Meningioma, Schwannoma
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors
A meningioma is a primary central nervous system (CNS) tumor. This means it begins in the brain or spinal cord. Overall, meningiomas are the most common type of primary brain tumor. However, higher grade meningiomas are very rare.
Schwannoma is a rare type of tumor that forms in the nervous system. Schwannoma grows from cells called Schwann cells. Schwann cells protect and support the nerve cells of the nervous system. Schwannoma tumors are often benign, which means they are not cancer. But, in rare cases, they can become can
Clinical Cancer Research
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003
PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG).
Cassie Kline, Payal Jain, Lindsay Kilburn, Erin R. Bonner, Nalin Gupta, John R. Crawford, Anu Banerjee, Roger J. Packer; Javier Villanueva-Meyer, Tracy Luks, Yalan Zhang, Madhuri Kambhampati, Jie Zhang, Sridevi Yadavilli, Bo Zhang, Krutika S. Gaonkar, Jo Lynne Rokita, Adam Kraya, John Kuhn, Winnie Liang; Sara Byron, Michael Berens, Annette Molinaro, Michael Prados, Adam Resnick, Sebastian M. Waszak, Javad Nazarian, Sabine Mueller
Children's Brain Tumor Network - Accelerating Research Through Collaboration and Open Science
This presentation highlights the impact and importance of the collaborative and open source nature of CBTN databases and samples.
Jena Lilly, Jennifer Mason, Elizabeth Appert, Allison Heath, Yuankun Zhu, Bo Zhang, Mateusz Koptyra, Mariarita Santi, Ian Pollack, Stewart Goldman, Sarah Leary, Anna Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Jiangguo Zhang, Weiqing Wan, Chunde Li, Ron Firestein, Jason Cain, Joanna Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey Greenfield, Brian Rood, Javad Nazarian, Eric Raabe, Eric Jackson, Stacie Stapleton, Robert Lober, David Kram, Phillip Storm, Rishi Lulla, Michael Prados, Adam Resnick, and Angela Waanders
An Integrated Set of Pediatric High Grade Glioma Resources for Translational Studies
In an effort to better support researchers around the world looking to understand pediatric high grade glioma, researchers have created a HGG resource that includes data and samples processed and provided by CBTN.
Heba Ijaz, Valerie Baubet, Mateusz Koptyra, Pichai Raman, Lamiya Tauhid, Krutika Gaonkar, Yuankun Zhu, Bo Zhang, Namrata Choudhari, Jamie Galanaugh, Elizabeth Appert, Jennifer Mason, Linnea Cripe, Taylor Lis, Maria Rita Santi, Jay Storm, Angela Waanders, Adam Resnick, and Kristina Cole