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Mark M. Souweidane

Weill Cornell Medicine
New York, NY, USA

CBTN Data

Backer

Alex's Lemonade Stand Foundation

About this

Project

The blood brain barrier (BBB) is a layer of cells that prevents substances from entering the fluid surrounding the brain. The goals of the project are to determine the BBB status of various pediatric brain tumor types, grades, and anatomic locations. Researchers will interrogate the underlying pathology leading to permeability of the BBB and investigate potential genomic correlates that may affect mechanisms that determine BBB permeability. Researchers expect this work to have a high clinical impact as the BBB is the major barrier to drug delivery and novel methods of delivery affect the BBB in different ways. Therefore, understanding the extent of BBB permeability will help to influence the selection of the method of drug delivery. A large cohort is necessary to find statistically significant associations, particularly when adjusting for false discovery for genomic correlates. Because these tumors are very rare, the Children’s Brain Tumor Network’s contribution of imaging data and unstained slide samples is an invaluable resource for studying these diseases.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

Researchers hope to better understand the BBB through analysis of the mechanisms that affect what can and can not pass through.

What is the impact of this project?

Better understanding of the BBB will allow for the development of new drug delivery methods that can more easily pass through, leading to more effective treatments.

Why is the CBTN request important to this project?

This research will be supported by the Children’s Brain Tumor Networks contributions of high quality imaging data and unstained slide samples necessary to complete this analysis.

Specimen Data

CBTN will contribute to this project by providing imaging data and unstained slides for staining.