Visiting Graduate Assistant in Neurological Surgery
Weill Cornell Medical College
Characterizing the Blood-Brain-Barrier in Pediatric Brain Tumors
We aim to determine how restrictive the blood-brain-barrier is in pediatric brain tumors using imaging, and to relate this to its histopathological and molecular characteristics. We hope that this will lead to a better understanding of the status of the blood-brain-barrier in pediatric brain tumors, thus potentially helping to select the best method of drug delivery for different tumors.
Mark M. Souweidane
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effectivenes
Low-Grade astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still suffer from the effect