Carl Koschmann

Dr. Koschmann is a Pediatric Neuro-Oncologist in the Department of Pediatrics and a Principal Investigator of an independent translational Pediatric Neuro-Oncology laboratory at the Chad Carr Pediatric Brain Tumor Center at the University of Michigan. His work in the clinic and lab complements and drive each other, resulting in a clear goal to improve therapies for children and young adults with brain tumors. Dr. Koschmann’s R01-funded lab investigates the molecular mechanisms by which mutations in pediatric high-grade glioma (pHGG), including diffuse midline glioma (DMG) and DIPG promote tumor growth and affect response to therapy. His lab uses novel genetically engineered animal and in vitro/organoid models to uncover genetically driven therapeutic biomarkers in this patient population. Additionally, he serves as the Co-PI/Co-I for multiple early phase studies in pHGG/DMG for which his lab performs analysis of correlate tumor and CSF samples. Much of this work has been with CBTN- and PNOC-affiliated collaborations. Dr. Koschmann co-chairs the PNOC/CBTN DMG Working Group. He is leading efforts to coordinate the integration of pediatric brain tumor sequencing datasets from U of M (MiOncoseq) within CBTN. Finally, his lab developed the CNS-TAP precision medicine algorithm tool, which is being employed in PNOC008 currently, and for which integration with CBTN is underway.