Jennison and Novak Families Professor of Neurosurgery; Director, Meningioma Center; Professor of Neurosurgery; Professor of Oncology
Johns Hopkins University School of Medicine
Identify key genetic pathways that are altered in brain tumors; Developing clinical trials to selectively target these pathways; Developing targeted therapies for patients with primary and metastatic tumors of the brain and spine; Ongoing clinical protocol to develop a simple blood test that can detect and monitor disease burden in patients with tumors affecting the central nervous system.
Johns Hopkins Medicine
Released Tumor DNA in the CSF for the Diagnosis and Monitoring of Pediatric Brain Tumors
The invasive nature of brain tumors points to a need for minimally invasive diagnostic and prognostic strategies. Using samples provided by the Children’s Brain Tumor Network, researchers will assess the usefulness of liquid biopsies in the care of pediatric medulloblastoma.
Determining Prognostic Factors and Genetic Markers that Impact Survival in Recurrent Pediatric Medulloblastoma
Research is needed in the development of targeted therapies and treatment protocols for patients with recurrent medulloblastoma. This project will work towards just that using access to extensive data from the Pediatric Brain Tumor Atlas.
Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature
Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
Researchers identify cerebrospinal fluid signatures that can be used to sensitively detect medulloblastoma.
Bongyong Lee, Iqbal Mahmud, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett & Ranjan J. Perera