Jessica B. Foster
Philadelphia, PA USA
About
Attending Physician at The Children's Hospital of Philadelphia; Instructor, Perelman School of Medicine at the University of Pennsylvania
The Children's Hospital of Philadelphia
Dr. Foster’s current research focuses on immunotherapy for pediatric solid and brain tumors. Specifically she is investigating chimeric antigen receptor (CAR) T cell therapy for neuroblastoma, high-grade gliomas, medulloblastomas, diffuse intrinsic pontine gliomas, and other brain tumors. The goals of her research are to develop pre-clinical CAR T cells for translation into clinical trials to help these devastating tumors.
scientific
Projects
Specimen
Molecular Characterization
Target Identification
Ongoing
GPC2 as an Immunotherapeutic Target in Medulloblastoma and other Pediatric Brain Tumors
GPC2 is a molecule expressed on the surface of cells in medulloblastoma and neuroblastoma cells. Researchers will analyze specimens provided by the Children’s Brain Tumor Network in an effort to determine whether GPC2 could serve as an immunotherapeutic target for the treatment of such tumors.
Medulloblastoma, HGG, (AT/RT)
Kristopher Bosse
research
Interests
HGG
High-Grade Glioma
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
