Resident PGY1, Department of Neurosurgery
University of Minnesota Medical School
Spatial evolution and somatic mutations spectrum of Gliomatosis Cerebri
The goal of this project is to do an analysis of the spatial evolution and genetic-epigenetic landscape in Gliomatosis Cerebri and other HGG. To do this, the team will use innovative tools in computational biology to map the spatial differences in glioma progression.
High-grade glioma/astrocytoma (WHO grade III/IV)
High-grade Gliomas (HGG) in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric specific HGG preclinical models. These models are needed to help test the effective