Biospecimen Unit Lead
Center for Data Driven Discovery in Biomedicine
Children’s Hospital of Philadelphia
Whole Genome Sequencing and RNA Sequencing of the CBTN Bank for the Pediatric Brain Tumor Atlas
Research into adult cancer has benefited greatly from large scale genomic research. Until now due to the limited resources and availability pediatric brain tumors have not been part of large-scale genomic generation efforts. The CBTN aims to create a comprehensive genomic atlas for use by researchers worldwide to unlock how brain tumors develop, grow, survive, and how they can be treated and cured.
Craniopharyngioma, Medulloblastoma, HGG, (AT/RT), LGG, Ependymoma, Ganglioglioma, DNET, Choroid Plexus Tumors, Meningioma, DIPG, Oligodendroglioma, Schwannoma, Germinoma, Choroid Plexus Tumors, Subependymal Giant cell Astrocytoma, NGGCTs
Telomere Length Analysis of CNS Tumors in the Pediatric Brain Tumor Atlas
Through analysis of data provided through the Pediatric Brain Tumor Atlas, researchers analyze the lengths of telomeres (structures that cap the ends of chromosomes) found in pediatric brain tumors as a way to identify therapeutic needs for various tumor types.
Rokita JL, Gaonkar K, Ijaz H, Miller D, Karras T, Santi M, Martinez D, Koptyra M, De Raedt T, Mason J, Appert E, Lilly J, Zhu Y, Waanders A, Resnick A, Storm J, Cole K.
Children's Brain Tumor Network - Accelerating Research Through Collaboration and Open Science
This presentation highlights the impact and importance of the collaborative and open source nature of CBTN databases and samples.
Jena Lilly, Jennifer Mason, Elizabeth Appert, Allison Heath, Yuankun Zhu, Bo Zhang, Mateusz Koptyra, Mariarita Santi, Ian Pollack, Stewart Goldman, Sarah Leary, Anna Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Jiangguo Zhang, Weiqing Wan, Chunde Li, Ron Firestein, Jason Cain, Joanna Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey Greenfield, Brian Rood, Javad Nazarian, Eric Raabe, Eric Jackson, Stacie Stapleton, Robert Lober, David Kram, Phillip Storm, Rishi Lulla, Michael Prados, Adam Resnick, and Angela Waanders
Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)
In an effort to increase access to high quality pediatric brain tumor samples, researchers describe samples and data prepared and provided through CBTN.
Heba Ijaz, Mateusz Koptyra, Krutika S. Gaonkar, Jo Lynne Rokita, Valerie P. Baubet, Lamiya Tauhid, Yankun Zhu, Miguel Brown, Gonzalo Lopez, Bo Zhang, Sharon J. Diskin, View ORCID ProfileZalman Vaksman, Children’s Brain Tumor Tissue Consortium, Jennifer L. Mason, Elizabeth Appert, Jena Lilly, Rishi Lulla, Thomas De Raedt, Allison P. Heath, Alex Felmeister, Pichai Raman, Javad Nazarian, Maria Rita Santi, Phillip B. Storm, Adam Resnick, Angela J. Waanders, Kristina A. Cole
An Integrated Set of Pediatric High Grade Glioma Resources for Translational Studies
In an effort to better support researchers around the world looking to understand pediatric high grade glioma, researchers have created a HGG resource that includes data and samples processed and provided by CBTN.
Heba Ijaz, Valerie Baubet, Mateusz Koptyra, Pichai Raman, Lamiya Tauhid, Krutika Gaonkar, Yuankun Zhu, Bo Zhang, Namrata Choudhari, Jamie Galanaugh, Elizabeth Appert, Jennifer Mason, Linnea Cripe, Taylor Lis, Maria Rita Santi, Jay Storm, Angela Waanders, Adam Resnick, and Kristina Cole