Mark M. Souweidane
New York, NY, USA
Weill Cornell Medicine
About
Vice Chairman of the Department of Neurological Surgery and the Director of Pediatric Neurological Surgery
Weill Cornell Medicine
Dr. Souweidane’s pediatric neurosurgery research lab, which is part of the Children's Brain Tumor Project, is focused on the promise of local delivery in treating brain tumors in children
Expertise
Neuro-oncology, Neurosurgery
Weill Cornell Medicine
scientific
Projects
Data
Ongoing
Spatial Evolution and Somatic Mutations Spectrum of Gliomatosis Cerebri
The development of treatment for Gliomatosis cerebri and other high grade gliomas relies on a comprehensive understanding of each tumor type. Using the Pediatric Brain Tumor Atlas alongside other open access datasets, researchers will map and analyze how tumors change over time, across locations, and the specific proteins created in Gliomatosis cerebri.
Ependymoma, DIPG
Jeffrey Greenfield
Specimen
Ongoing
Choroid Plexus Tumor (CPT) Therapies Based on Patient-derived Cell Culture Resources
Choroid plexus tumors, including choroid plexus carcinoma, are rare tumors with limited treatment options. Researchers will use tissue provided by the Children’s Brain Tumor Network to establish cell lines that will be used to propel research into CPT treatment forward.
Mark M. Souweidane
Data
Specimen
Planning
Characterizing the Blood-Brain-Barrier in Pediatric Brain Tumors
The blood brain barrier is an issue clinicians face when trying to deliver drugs for the treatment of brain cancers. Using rare samples and imaging data provided by the Children’s Brain Tumor Atlas, researchers will investigate new avenues for drug delivery.
HGG, LGG
Mark M. Souweidane
research
Interests
Craniopharyngioma
Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).Craniopharyngiomas are usually part solid mass and
Low-Grade Glioma
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
Diffuse Intrinsic Pontine Glioma
A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained for both entry into research studies and molecular characterization of the tumor.[5] New approaches with