Pediatric thalamic tumors are relatively rare cancers and are classified as either low grade gliomas (LGG) or high grade gliomas (HGG). Bilateral thalamic gliomas (BTG) are a particularly rare tumor in this group. Recent molecular studies and WHO classification places thalamic tumors in the category of midline gliomas such as diffuse intrinsic pontine gliomas (DIPGs). This new categorization has been mainly based on discoveries that show histone 3 mutations to drive both of these tumors types. Where recent studies have identified histone mutations associated with DIPGs, more research is required to provide a clear landscape of genomic aberrations associated with thalamic tumors. The goals of this project are to generate the comprehensive molecular profile specific to primary thalamic tumors and to validate genomic abnormalities using liquid biopsy and whole exome sequencing (DNA from blood samples). This project is a comprehensive study of the biology of thalamic glioma and understanding its genetic background. This understanding could lead to more accurate diagnostics and more effective treatment options for patients. The Children's Brain Tumor Network contributed to this project by providing rare plasma samples, tumor tissue, tumor DNA, cerebral spinal fluid and germline DNA.
What are the goals of this project?
Recent studies have reclassified thalamic tumors as midline gliomas and this project seeks to further analyze genomics of these tumors in an effort to develop targeted therapies and test a new approach to diagnosis these tumors using a liquid biopsy which would be a less invasive diagnostic approach as opposed to surgery.
What is the impact of this project?
This research will expand upon recent insight into thalamic tumors in an effort to develop more accurate diagnostics and targeted treatment options.
Why is the CBTN request important to this project?
The samples needed to carry out this research are rare, which is why the Children’s Brain Tumor Networks contribution to this project is so important.
The Children's Brain Tumor Network contributed to this project by providing plasma samples, tumor tissue, tumor DNA, cerebral spinal fluid and germline DNA.
Javad Nazarian, PhD, MSc
I am an investigator at the Center for Genetic Medicine in Children’s National Hospital in Washington, D.C., and an assistant professor in Integrative Systems Biology at the George Washington University. I received my PhD from the George Washington University in Genetics in 2005. My dissertation res
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