Pediatric Brain Tumor miRNA Profiling for the Cohort of Children’s Brain Tumor Network Specimens
Email Principal Investigator

Mateusz Koptyra
CBTN Specimen
CBTN Participants
CBTN Samples
Backer
Institutional Funds
About this
Project
The leading cause of disease related death in children is pediatric brain tumors. Surgery remains the main form of treatment for such tumors, however many brain tumors are unable to be fully removed with surgery. There are many factors that could lead to new and more effective therapies, including greater understanding of tumor genetics, comprehensive preclinical tests, and sensitive methods to assess tumor response to treatment. Mapping tumor molecular characteristics towards the discovery of tumor-related biomarkers, or observable changes in the body related cancer progression could lead to advancements in therapies, preclinical tests, and ongoing assessments. Using RNA samples provided by CBTN, researchers will produce a significant amount of biomarker data to be used in pediatric cancer research around the world.
Ask The
Scientists
What are the goals of this project?
The CBTN samples for this project have genomic data generated and associated with each, researchers seek to add RNA sequencing data for all of these samples in an effort to further characterize the tumors and to drive biomarker discovery.
What is the impact of this project?
Mapping tumor molecular characteristics and discovery and analysis of tumor-related biomarkers could lead to advancements in therapies, preclinical tests, and ongoing assessments.
Why is the CBTN request important to this project?
The RNA samples provided by CBTN will be integral to the data collection and analysis of this project.
Specimen Data
The Children's Brain Tumor Network contributed to this project by providing RNA samples for the generation of miRNAseq.
Meet The
Team
Institutions
related
Histologies
HGG
High-Grade Glioma
High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test
LGG
Low-Grade Glioma
Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su
Ependymoma
Ependymoma
Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors
related
Resources
Project
false,Craniopharyngioma, Medulloblastoma, HGG, (AT/RT), LGG, Ependymoma, Ganglioglioma, DNET, Schwannoma

Adam Resnick