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Mateusz Koptyra

Children’s Hospital of Philadelphia
Philadelphia, PA, USA

CBTN Specimen

235

CBTN Participants

264

CBTN Samples

Backer

Institutional Funds

About this

Project

The leading cause of disease related death in children is pediatric brain tumors. Surgery remains the main form of treatment for such tumors, however many brain tumors are unable to be fully removed with surgery. There are many factors that could lead to new and more effective therapies, including greater understanding of tumor genetics, comprehensive preclinical tests, and sensitive methods to assess tumor response to treatment. Mapping tumor molecular characteristics towards the discovery of tumor-related biomarkers, or observable changes in the body related cancer progression could lead to advancements in therapies, preclinical tests, and ongoing assessments. Using RNA samples provided by CBTN, researchers will produce a significant amount of biomarker data to be used in pediatric cancer research around the world.

Ask The

Scientists

Ask the scientists

What are the goals of this project?

The CBTN samples for this project have genomic data generated and associated with each, researchers seek to add RNA sequencing data for all of these samples in an effort to further characterize the tumors and to drive biomarker discovery.

What is the impact of this project?

Mapping tumor molecular characteristics and discovery and analysis of tumor-related biomarkers could lead to advancements in therapies, preclinical tests, and ongoing assessments.

Why is the CBTN request important to this project?

The RNA samples provided by CBTN will be integral to the data collection and analysis of this project.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing RNA samples for the generation of miRNAseq.

related

Histologies

Craniopharyngioma.png

Craniopharyngioma

Childhood craniopharyngiomas are rare tumors usually found near the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).Craniopharyngiomas are usually part solid mass and

129
Participants
6
Projects Supported
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Medulloblastoma

Medulloblastomas comprises the vast majority of pediatric embryonal tumors and by definition arise in the posterior fossa, where they constitute approximately 40% of all posterior fossa tumors. Other forms of embryonal tumors each make up 2% or less of all childhood brain tumors.The clinical feature

443
Participants
35
Projects Supported
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High-Grade Glioma

High-grade Gliomas (HGG) or astrocytomas in children nearly always result in a dismal prognosis. Although novel therapeutic approaches are currently in development, preclinical testing has been limited, due to a lack of pediatric-specific HGG preclinical models. These models are needed to help test

348
Participants
62
Projects Supported
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Atypical Teratoid/Rhabdoid Tumor

Central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT) is a very rare, fast-growing tumor of the brain and spinal cord. It usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of these tumors form in the cerebellum or

100
Participants
13
Projects Supported
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Low-Grade Glioma

Low-Grade Gliomas also called astrocytomas are the most common cancer of the central nervous system in children. They represent a heterogeneous group of tumors that can be discovered anywhere within the brain or spinal cord. Although surgical resection may be curative, up to 20% of children still su

1003
Participants
23
Projects Supported
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Ependymoma

Ependymomas arise from ependymal cells that line the ventricles and passageways in the brain and the center of the spinal cord. Ependymal cells produce cerebrospinal fluid (CSF). These tumors are classified as supratentorial or infratentorial. In children, most ependymomas are infratentorial tumors

319
Participants
22
Projects Supported
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Ganglioglioma

Ganglioglioma presents during childhood and into adulthood. It most commonly arises in the cerebral cortex and is associated with seizures, but also presents in other sites, including the spinal cord.[65,74]The unifying theme for the molecular pathogenesis of ganglioglioma is genomic alterations lea

185
Participants
7
Projects Supported
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Dysembryoplastic Neuroepithelial Tumor

Septal DNET generally presents with symptoms related to obstructive hydrocephalus.[69,70] Septal DNET has an indolent clinical behavior, with most tumors not requiring treatment other than surgery. In a single-institution series that incorporated other literature-reported cases, the median age at pr

76
Participants
6
Projects Supported
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Schwannoma

Schwannoma is a rare type of tumor that forms in the nervous system. Schwannoma grows from cells called Schwann cells. Schwann cells protect and support the nerve cells of the nervous system. Schwannoma tumors are often benign, which means they are not cancer. But, in rare cases, they can become can

54
Participants
6
Projects Supported