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Mateusz Koptyra

Children’s Hospital of Philadelphia
Philadelphia, PA, USA

CBTN Specimen


CBTN Participants


CBTN Samples


Institutional Funds

About this


The leading cause of disease related death in children is pediatric brain tumors. Surgery remains the main form of treatment for such tumors, however many brain tumors are unable to be fully removed with surgery. There are many factors that could lead to new and more effective therapies, including greater understanding of tumor genetics, comprehensive preclinical tests, and sensitive methods to assess tumor response to treatment. Mapping tumor molecular characteristics towards the discovery of tumor-related biomarkers, or observable changes in the body related cancer progression could lead to advancements in therapies, preclinical tests, and ongoing assessments. Using RNA samples provided by CBTN, researchers will produce a significant amount of biomarker data to be used in pediatric cancer research around the world.

Ask The


Ask the scientists

What are the goals of this project?

The CBTN samples for this project have genomic data generated and associated with each, researchers seek to add RNA sequencing data for all of these samples in an effort to further characterize the tumors and to drive biomarker discovery.

What is the impact of this project?

Mapping tumor molecular characteristics and discovery and analysis of tumor-related biomarkers could lead to advancements in therapies, preclinical tests, and ongoing assessments.

Why is the CBTN request important to this project?

The RNA samples provided by CBTN will be integral to the data collection and analysis of this project.

Specimen Data

The Children's Brain Tumor Network contributed to this project by providing RNA samples for the generation of miRNAseq.