The leading cause of disease related death in children is pediatric brain tumors. Surgery remains the main form of treatment for such tumors, however many brain tumors are unable to be fully removed with surgery. There are many factors that could lead to new and more effective therapies, including greater understanding of tumor genetics, comprehensive preclinical tests, and sensitive methods to assess tumor response to treatment. Mapping tumor molecular characteristics towards the discovery of tumor-related biomarkers, or observable changes in the body related cancer progression could lead to advancements in therapies, preclinical tests, and ongoing assessments. Using RNA samples provided by CBTN, researchers will produce a significant amount of biomarker data to be used in pediatric cancer research around the world.
What are the goals of this project?
The CBTN samples for this project have genomic data generated and associated with each, researchers seek to add RNA sequencing data for all of these samples in an effort to further characterize the tumors and to drive biomarker discovery.
What is the impact of this project?
Mapping tumor molecular characteristics and discovery and analysis of tumor-related biomarkers could lead to advancements in therapies, preclinical tests, and ongoing assessments.
Why is the CBTN request important to this project?
The RNA samples provided by CBTN will be integral to the data collection and analysis of this project.
The Children's Brain Tumor Network contributed to this project by providing RNA samples for the generation of miRNAseq.
Mateusz Koptyra, PhD
Dr. Mateusz Koptyra is a Senior Scientist responsible for initiation, coordination and implementation of scientific projects around the Center’s research units. His team identifies the research demands at the clinical level and creates pipelines for projects to test the research proposals at a pre-c
Children’s Hospital of Philadelphia
Adam Resnick, PhD
Adam Resnick is the Director of Data Driven Discovery in Biomedicine (D3b) at Children’s Hospital of Philadelphia (CHOP) responsible for leading a multidisciplinary team to build and support a scalable, patient-focused healthcare and educational discovery ecosystem on behalf of all children. He is a
Children’s Hospital of Philadelphia
Children’s Hospital of PhiladelphiaJoined on
Operations Center for the Children’s Brain Tumor Tissue Consortium, the Children’s Hospital of Philadelphia (CHOP) is currently ranked 1st nationally for their Pediatric Cancer Program by U.S. News & World Report. CHOP’s Biobank is home to the CBTTC’s pediatric brain and CNS tumor biorepository; the
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Children's Brain Tumor Network Pediatric Brain Tumor Proteomics Pilot
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Craniopharyngioma, Medulloblastoma, HGG, (AT/RT), LGG, Ependymoma, Ganglioglioma, DNET, Schwannoma